Methotrexate-related pulmonary complications in rheumatoid arthritis.
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چکیده
منابع مشابه
Methotrexate-related pulmonary complications in rheumatoid arthritis.
Methotrexate (MTX) was described as a drug in 1946' and first used in the treatment of human disease (childhood leukaemia) in 1948.2 Successful MTX treatment for rheumatoid arthritis (RA) and psoriasis was reported in 1951,3 although the interest in this drug at that time was probably overshadowed by the impressive results of cortico-steroid treatment until approximately 1980. MTX was approved ...
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Background:Methotrexate (MTX) is one of the most commonly used disease-modifying antirheumatic drugs in the treatment of rheumatoid arthritis (RA) which can be associated with toxic effects on different organs. This study was designed to investigate the hepatotoxic effects in RA patients treated with MTX. Methods: In this cross-sectional observational study, RA patients who received standard d...
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A variety of disease-modifying antirheumatic drugs (DMARDs) are available to control the clinical activity of rheumatoid arthritis (RA). Methotrexate (MTX), an analogue of folic acid and of aminopterin, is the most commonly used DMARD and is now prescribed worldwide to at least 500,000 patients with RA. The mechanism by which MTX used at a low dose modulates inflammation in RA is still unknown....
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Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease whose distinctive feature is the development of symmetrical polyarthritis. It has a prevalence of 1% in the general population, predominating in females and peaking between the ages of 30 and 50 years; it is found worldwide, although some ethnic groups show an increased propensity for the disease. The burden of illness in thes...
متن کاملmethotrexate hepatotoxicity in patients with rheumatoid arthritis
background increases in aminotransferases (transaminitis) are potential major adverse reactions seen with long-term use of methotrexate (mtx). the aim of this study, therefore was to evaluate the incidence of mtx induced hepatotoxicity and its risk factors among rheumatoid arthritis (ra) patients. methods this retrospective study described 286 patients with ra who received ≤ 7.5 mg mtx weekly...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1994
ISSN: 0003-4967
DOI: 10.1136/ard.53.7.434